Inés de Lannoy is Vice President of Research and Development for InterVivo Solutions and has both pharmacokinetics (PK) and drug discovery experience, having worked at a number of biopharmaceutical companies and contract research organizations (CROs) over the past 25 years. In previous roles, she was responsible for building the in vivo PK, in vitro ADME, high throughput screening and bioanalytical capabilities of CROs, for providing as a service to pharmaceutical clients. While at Allelix Biopharmaceuticals (now NPS Pharmaceuticals), she advanced several drug candidates from discovery into clinical trials. Inés strives to develop new pre-clinical models/methods for the more accurate and facile characterization of human PK. She has expertise in the transport of xenobiotics across the blood-brain barrier, an area in which she has a keen research interest. She also serves on the editorial boards of Biopharmaceutics and Drug Disposition, Biochemical Pharmacology and Current Protocols in Pharmacology.
Inés is Assistant Professor (Status) and Associate (Restricted) Member of the Graduate Department of Pharmaceutical Sciences in the Leslie Dan Faculty of Pharmacy at the University of Toronto.
Selected Publications
Arastu-Kapur S, Nguyen M, Raha D, Ermini F, Haditsch U, Araujo J, De Lannoy IAM, Ryder MI, Dominy SS, Lynch C, Holsinger LJ. Treatment of Porphyromonas gulae infection and downstream pathology in the aged dog by lysine-gingipain inhibitor COR388. Pharmacol Res Perspect. 8(1): e00562 (2020)
Fletcher, PJ, Li X., Selinieks, L., MacMillan, C., de Lannoy, I, Higgins G. Preclinical evidence for combining the 5-HT-2C receptor agonist lorcaserin and varenicline as a treatment for nicotine dependency. Addiction Biol. 24(3):376 (2019).
Higgins GA, Silenieks LB, Patrick A, de Lannoy IAM, Fletcher PJ, Parker LA, MacLusky NJ, Sullivan LC, Chavera TA, Berg KA. Studies to examine potential tolerability differences between the 5-HT2C receptor selective agonists Lorcaserin and CP-809101. ACS Chem Neurosci. 8(5):1074 (2017).
Bessonneau V, Zhan Y, De Lannoy IA, Saldivia V, Pawliszyn J. In vivo solid-phase microextraction liquid chromatography-tandem mass spectrometry for monitoring blood eicosanoids time profile after lipopolysaccharide-induced inflammation in Sprague-Dawley rats. J Chromatogr A. 11(1424):134 (2015).
Higgins, G.A., Desnoyer, J., Van Niekerk, A., Silenieks, L.B., Lau, W., Thevarkunnel, S., Izhakova, J., de Lannoy, I.A.M., Fletcher, P.J. Delay, J. and Dobson, H. Characterization of the 5-HT2C receptor antagonist lorcaserin on efficacy and safety measures in a rat model of diet-induced obesity. Pharmacol Res Perspect. 3(1): e00084. doi:10.1002/prp2.84 (2015)
Durk, M.R., Fan, J., Sun, H., Yang, Y., Pang, H., Pang, K.S. and de Lannoy, I.A.M. The vitamin D receptor induces P-glycoprotein and increases brain efflux of qunidine: an intracerabral microdialyis study in conscious rats. Pharm. Res. 32(3): 1128 (2015).
Aimone, L.D. and de Lannoy, I.A.M. Overview of Pharmacokinetics. Curr Protocol. Pharmacol. 66:7.1.1-7.1.31 (2014).
Fan, J. and de Lannoy, I.A.M. Pharmacokinetics. Special Issue – Pharamacology in 21st Century Biomedical Research. Biochem. Pharmacol. 87(1): 93-120 (2014).
Chan, G.N.Y., Saldivia, V., Yang, Y., Pang, H., de Lannoy, I., and Bendayan, R. In vivo induction of P-glycoprotein expression at the mouse blood-brain barrier: an intracerebral microdialysis study. J. Neurochem. 127(3): 342-352 (2013).