Forensic Toxicology – Method development for the accurate determination of drugs in biological samples have been examined. Current collaboration with the various Forensic Laboratories in Canada are in existence. For example, the Centre for Forensic Science in Toronto and the R.C.M.Police Forensic Laboratories. A recent manuscript (J. Anal. Toxicology, 2002) describes a general screening method for acidic, neutral and basic drugs from whole blood using the Oasis MCX Column. Of the drugs tested 75% were extractable from whole blood and detectable at therapeutic concentrations.
Other research carried out in the laboratory includes:
Neonatal Research – The effects of medications on the neonate. Extensive studies were completed on the effects of chloral hydrate in the pediatric population. Contrary to that reported in the adult, chloral hydrate was detectable for several hours after oral administration. The t ? for the major metabolite, trichloroethanol (TCE) is three to four times greater than that seen in the adult. Another metabolite, trichloroacetic acid (TCA) had a remarkable long residence time in this study population.
Drug-Interactions – Drug interaction studies have provided some plausible theories for drug misuse/abuse. The interaction between antihistamines (OTC’s) and prescription medication in animals and human were the subject of extensive publications.
Drug Prevalence – Drug prevalence in elementary, junior and senior high and university students have been conducted. A recent survey of pharmacy students in Canada provided the first survey of this type of research in a health professional student body.
Leslie Dan Faculty of Pharmacy
University of Toronto
144 College Street
Toronto, Ontario, M5S 3M2