K. Sandy Pang
Application of Pharmakokinetics and Pharmacodynamics to Study Drug Transport, Metabolism, and the Vitamin D Receptor
K. Sandy Pang, Ph.D., received her B.Sc. (Pharmacy) from the University of Toronto, Ph.D. (Pharm Chem) from the University of California at San Francisco and further postdoctoral training as a Fogarty fellow at the National Institutes of Health, Bethesda, MD. After working the next four years at the Texas Medical Centre, Houston, she returned to Toronto and has been a Professor of Pharmacy and Pharmacology at the Faculties of Pharmacy and Medicine since 1987. Dr. Pang applies pharmacokinetic theory to understand the roles that transporters and enzymes play in the disposition of drugs and metabolites in eliminating organs and brain. Uptake from transporter and metabolism are examined in vitro from transfection systems, subcellular preparations (Western blotting), zonal isolated rat hepatocytes, cell-cultured systems, perfused organs and transgenic or chimeric animals. Her specialty in pharmacokinetics dwells on organ and whole body clearance concepts and metabolite kinetics. Her laboratory has developed physiologically-based models that include transporters and enzymes and their heterogeneity, as well as binding (vascular protein, red blood cell and tissue) to explain route-dependent metabolism of drugs during intestinal absorption. Her recent research is on the liver and brain as new therapeutic and molecular targets of the vitamin D receptor (VDR), first relating to how levels of the VDR ligand 1,25-dihydroxyvitamin D3 affects its synthetic (CYP27B1) and catabolic (CYP24A1) enzymes (pharmacodynamics) and how the enzymes affect levels. PKPD modeling is being developed to predict the lowering of cholesterol and brain β-amyloids by the VDR.
She serves as the Editor in Chief of Biopharmaceutics and Drug Disposition, Editor of the British Journal of Pharmcaology, and a member of the Editorial Review Board Drug Metabolism and Disposition, the AAPS Journal, and Xenobiotica. She is a fellow of AAAS and AAPS. She was the recipient of the NIH Research Career Development Award, Faculty Development award from the Medical Research Council of Canada, the McNeil Award from the Faculties of Pharmacies in Canada, the Research Achievement Award in Pharmacokinetics, Pharmacodynamics and Drug Metabolism (PPDM) from the American Association of Pharmaceutical Scientists (AAPS), Service Award of the PPDM at AAPS, and the Nagai Foundation lectureship.
Leslie Dan Faculty of Pharmacy
University of Toronto
144 College Street
Toronto, Ontario, M5S 3M2