In this area our teams are elucidating the biochemical and cellular basis of human diseases and the molecular mechanisms underlying drug action and their targets.
Our investigation of disease mechanisms provides insights into identification of novel therapeutic targets for which small molecules or biologics are being developed. Research is directed towards the molecular and cellular mechanisms underlying the function of therapeutic targets, correcting the target using gene therapy, and the intracellular signalling pathways they control and the mechanistic study of drug action. Approaches incorporate human studies, patient-derived samples and animal models of disease. Our research teams are interested in several human diseases or conditions including drug addiction, autism, diabetes, cancer, genetic disorders, infectious diseases, and neurological diseases.
Investigators
Research News
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Canadian Hub for Health Intelligence and Innovation in Infectious Diseases awarded $72 million
Biomanufacturing Hub Network (BioHubNet), a CBRF-funded program led by University Professor and Scientific Director of PRiME Molly Shoichet, will address the severe shortage of talents in the biomanufacturing sector.
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Team Rx Participate wins 2024 Business Plan Competition
PharmD students Saphia Mourad, Cynthia Nohra, Lama Alomrani, and Maneli Jafar-Pisheh, collectively known as Team Rx Participate, won the top prize at the annual Business Plan Competition finale.
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U of T researchers target neurogenesis in new approach to treat Parkinson’s disease
Researchers at the Temerty Faculty of Medicine found a way to better control the preclinical generation of key neurons depleted in Parkinson’s disease.
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