In this area our teams are elucidating the biochemical and cellular basis of human diseases and the molecular mechanisms underlying drug action and their targets.
Our investigation of disease mechanisms provides insights into identification of novel therapeutic targets for which small molecules or biologics are being developed. Research is directed towards the molecular and cellular mechanisms underlying the function of therapeutic targets, correcting the target using gene therapy, and the intracellular signalling pathways they control and the mechanistic study of drug action. Approaches incorporate human studies, patient-derived samples and animal models of disease. Our research teams are interested in several human diseases or conditions including drug addiction, autism, diabetes, cancer, genetic disorders, infectious diseases, and neurological diseases.
Investigators
Research News
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Faces of PharmSci: Kinda Karra
MScPhm student Kinda Karra, working with Clinician Scientist Carlo DeAngelis, is studying why some breast cancer patients experience pain after chemotherapy and how a small blood sample could help detect signs of this reaction.
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Trade tariffs on pharmaceuticals ‘not the way to go’: U of T expert releases new study showing disruptions and cost increases
Trade tariffs on Canadian pharmaceuticals expected to increase costs in the U.S. and strain drug supply chains.
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Northern Ontario rotation inspires new perspective on pharmacy practice
Alina Montgomery’s rotation on Manitoulin Island demonstrated the importance of pharmacists in northern communities
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