In this area our teams are elucidating the biochemical and cellular basis of human diseases and the molecular mechanisms underlying drug action and their targets.
Our investigation of disease mechanisms provides insights into identification of novel therapeutic targets for which small molecules or biologics are being developed. Research is directed towards the molecular and cellular mechanisms underlying the function of therapeutic targets, correcting the target using gene therapy, and the intracellular signalling pathways they control and the mechanistic study of drug action. Approaches incorporate human studies, patient-derived samples and animal models of disease. Our research teams are interested in several human diseases or conditions including drug addiction, autism, diabetes, cancer, genetic disorders, infectious diseases, and neurological diseases.
Carlo DeAngelis' research is exploring the value of virtual clinical pharmacy services and determining which groups of patients benefit most from virtual clinical pharmacy consultation services.Read More
Post-doctoral Fellow Amin GhavamiNejad discusses leading the Diabetes research subgroup in the Wu lab with the goal of developing affordable, clinically-translatable products to benefit diabetes patients.Read More